Epigenetically altered miR-1247 functions as a tumor suppressor in pancreatic cancer

Altered expression of microRNAs has been strongly implicated in human cancers, and growing evidence is emerging that a number of miRNAs are downregulated in cancer associated with CpG island hypermethylation. Although pancreatic cancer is one of the most malignant human cancers, the roles of miRNAs underlying the tumorigenesis of pancreatic cancer are still poorly understood. In the present stu...

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miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKα1.

miRNAs are small noncoding RNAs that participate in a variety of biologic processes, and dysregulation of miRNA is always associated with cancer development and progression. Aberrant expression of miR-148b has been found in some types of cancer, but its expression and potential biologic role in pancreatic cancer are still largely unknown. In this study, our data showed that miR-148b was signifi...

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Companion Diagnostics and Cancer Biomarkers miR-148b Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting AMPKa1

miRNAs are small noncoding RNAs that participate in a variety of biologic processes, and dysregulation of miRNA is always associated with cancer development and progression. Aberrant expression of miR-148b has been found in some types of cancer, but its expression and potential biologic role in pancreatic cancer are still largely unknown. In this study, our data showed thatmiR-148bwas significa...

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Companion Diagnostics & Cancer Biomarkers miR-148b Functions as a Tumor Suppressor in Pancreatic Cancer by Targeting AMPKa1

miRNAs are small noncoding RNAs that participate in a variety of biologic processes, and dysregulation of miRNA is always associated with cancer development and progression. Aberrant expression of miR-148b has been found in some types of cancer, but its expression and potential biologic role in pancreatic cancer are still largely unknown. In this study, our data showed thatmiR-148bwas significa...

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Tumor suppressor functions of miR-133a in colorectal cancer.

UNLABELLED Dysregulated microRNA (miRNA) expression was profiled through a miRNA array comparison between human colorectal cancer tumors and their adjacent normal tissues. Specifically, using laser capture micro-dissection, miR-133a was shown to be significantly downregulated in primary colorectal cancer specimens compared with matched adjacent normal tissue. Ectopic expression of miR-133a sign...

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Epigenetically altered miR-1247 functions as a tumor suppressor in pancreatic cancer

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